The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy and climate, health innovation and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major challenges facing society, science and economy. PSI is committed to the training of future generations. Therefore, about one quarter of our staff are post-docs, post-graduates or apprentices. Altogether, PSI employs 2300 people.
For the Nanodiffraction Group in the Multiscale Bioimaging Laboratory LMB, we are looking for a
Postdoctoral Fellow in Biophysics
Your tasks
In this position, you will work at the interface of experimental biophysics, structural biology, artificial intelligence, and pharmaceutical formulation science. Your main responsibilities will include:
* Characterization of biologics (antibodies, proteins, siRNA) in the presence of excipients using SAXS and complementary biophysical techniques
* Development and validation of a predictive pipeline for excipient–biologic interactions
* Integration of experimental SAXS data with AI-driven structural modeling to predict oligomerization behavior and excipient effects
* Close collaboration with the industrial partner Excelsus Structural Solutions to translate experimental workflows into formulation-related services
* Participation in experimental planning, quality control, and iterative excipient screening
* Presentation of scientific results at international conferences and contribution to peer-reviewed publications
* Co-supervision and scientific support of PhD and master’s students
Your profile
Required qualifications:
* PhD degree in Bioinformatics, Artificial Intelligence, Biochemistry, Biophysics, Pharmaceutical Sciences, or a related field
* Strong background in protein or nucleic acid biophysics and structural characterization
* Experience with computational modeling and data analysis
* Excellent command of English, written and spoken
Additional qualifications:
* Experience in protein or biologics formulation
* Knowledge of SAXS, light scattering, or other solution-state biophysical characterization methods
* Familiarity with AI-driven modeling tools (e.g., AlphaFold Multimer, Rosetta) and/or molecular dynamics simulations
* Interest in translational research and industrial collaboration
We offer
Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.
Your employment contract is limited to 2 years with the possibility of extension for 1 year.
For further information, please contact Dr Jinghui Luo, phone +41 56 310 47 64.
Please submit your application online by5 April2026(including a cover letter, a list of publications and addresses of referees) for the position as a Postdoctoral Fellow (Index-Nr. 2411-25744).
Paul Scherrer Institute, Human Resources Management, Serdal Varol, 5232 Villigen PSI, Switzerland
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