Project Assistant - Doctoral Candidate (m/f/d) in the project of MetAGE: Metabolic regulation of spermidine and hypusination
* Duration of Contract: Temporary employment
* Temporary Employment: 1 Year with the option of extension
Your Responsibilities
* Conducting and writing a dissertation at the University of Graz under the supervision of Univ. Prof. Frank Madeo
* Perform experiments and data analyses
* Plan and evaluate scientific experiments independently
* Present and discuss data at internal and external meetings as well as (inter)national conferences
* Publish in peer-reviewed international journals
* Co-supervise students working on Bachelor’s or Master’s projects
* Opportunity to perform part of the project in a host laboratory abroad
Your Profile
* Completed diploma or master’s degree in life sciences or natural sciences
* Eligible as a graduate student at the University of Graz, Austria
* Theoretical and practical knowledge in biochemistry, molecular and cell biology
* Ideally, practical experience with mouse models
* High commitment, initiative, and motivation for scientific work
* Excellent command of written and spoken English
* Responsibility and teamwork skills
Application Documents
* Motivation letter, including project preferences if multiple applications
* Academic CV with abstract of Master Thesis
* Proof of degree completion
* Two recommendation letters sent directly by referees to metAGE@uni-graz.at by the deadline
Hearing Date: 23 June 2025 in Graz
Project Description:
Background: Spermidine is a molecule with health benefits, involved in various cellular processes, but its distribution and effects on aging and nutrition are not fully understood.
Hypothesis and Objectives: We hypothesize that metabolic pathways regulate eIF5A hypusination, affecting cellular functions. Objectives include exploring spermidine differences in metabolic scenarios, subcellular distribution under nutritional cues, and linking these to hypusination, including studies in mouse models.
Methodology: Techniques include cell fractionation, metabolite analysis, and developing novel detection methods for hypusination.
References:
1. Madeo, F., Eisenberg, T., Pietrocola, F. & Kroemer, G. Spermidine in health and disease. Science 359, eaan2788 (2018).
2. Eisenberg, T. et al. Cardioprotection and lifespan extension by spermidine. Nat Med 22, 1428–1438 (2016).
3. Hofer, S. et al. Spermidine is essential for autophagy and longevity. Nat Cell Biol (2024).
We offer an annual gross salary of €52,007.20 for a full-time position.
About us: The University of Graz employs 4700 staff working on future-oriented research and education. Join us to be part of shaping tomorrow!
Contact: The university encourages women and persons with disabilities to apply, offering equal opportunities. Applications are accepted only via the web-based applicant tool. We work for tomorrow. Join us!
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